Featured Services

Protein Purification
Bacterial Expression System
Soluble protein expression, supernatant optimization, endotoxin removal, inclusion body refolding
Antibody Production
Mammalian Expression System
Rapid protein production, multiple transfection methods, high transfection efficiency, mRNA structure optimization
Protein expression
Recombinant Antibody Production
One-stop service from gene to antibody, high expression vector, codon optimization, high specificity
Molecular biology platform
Stable Cell Line Development
Dozens of cell types transfection experience, screening out positive cell pool or single cell clones
Recombinant Antibody Production
We provide various types of recombinant antibody production services. We produce full length antibodies and fragment antibodies, e.g. scFv, Fab, you only need to provide sequences. Our antibody can be applied to affinity Analysis, activity assay and interaction studies.
Mammalian Expression System
We provide prokaryotic expression services, including expression of soluble proteins and tag-free proteins, large-scale fermentation. We guarantee delivery of a soluble proteins. If the protein is not soluble, you will not be charged. The shortest time to delivery is only 5 weeks.
Recombinant Antibody Production
We provide protein transient transfection expression in mammalian cell. We are equipped with a 100-grade clean cell room. Through engineering regulatory elements in HEK293 and CHO cells, proteins with a variety of complex modifications can be expressed, allowing rapid production of highly active proteins in small quantities.
Biomolecular Interaction Analysis
We provide molecular interactions analysis services, including protein-small molecule, protein-protein, and antigen-antibody interactions. We can carry out in vivo or in vitro interaction analysis, which allows us to examine intermolecular interactions both qualitatively and quantitatively (by determining affinity constants, Kd, Ka, and KD).
Antibody Production
We provide stable cell line construction services, including insertion or knockout of the gene of interest, as well as screening out positive cell pools or single cell clones . The shortest time to delivery is only 3 months.
Bioinformation Tools
We provide antigen and antibody production services. Our antibody production services include monoclonal (ELISA>1:128000) production and polyclonal antibodies (ELISA>1:64000). The final deliverable is 2-5 mg antibody.
bic introduction
Biologics International Corp (BIC) is a leading biotech company engaged in custom recombinant protein and antibody production for clients around the world across both academic institutions and biotech/pharmaceutical industries. The aim of BIC is to provide our clients the highest quality services yet with the precision, speed, and value, and build strong partnerships with our clients, focusing on development of cutting-edge technologies in expression, production, and manufacturing of recombinant proteins and antibodies. If you need any assistance, please contact us.
  1. Pendola M, Davidyants A, Jung Y S, et al. Sea Urchin Spicule Matrix Proteins Form Mesoscale “Smart” Hydrogels That Exhibit Selective Ion Interactions[J]. ACS Omega, 2017, 2(9): 6151-6158.
  2. Escolano J M, Díaz-Durán B, Demiguel-Ramos M, et al. Selection of aptamers to Neisseria meningitidis, and Streptococcus pneumoniae, surface specific proteins and affinity assay using thin film AlN resonators[J]. Sensors & Actuators B Chemical, 2017, 246:591-596.
  3. Porkka J. HSD17β1-inhibiittoreiden seulontamenetelmän kehitys[J]. 2016.
  4. Ruan H B, Ma Y, Torres S, et al. Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation[J]. Genes & Development, 2017, 31(16):1655.
  5. Jayaraj R, Smooker P M. So you need a protein-A guide to the production of recombinant proteins[J]. The open veterinary science journal, 2009, 3(7): 28-34.
  6. Jain G, Pendola M, Huang Y C, et al. A Model Sea Urchin Spicule Matrix Protein, rSpSM50, Is a Hydrogelator That Modifies and Organizes the Mineralization Process[J]. Biochemistry, 2017, 56(21):2663.
  7. Farmanbar N, Haddad-Mashadrizeh A, Hemmat J. An in-silico investigation on the structure, function and homologous sequences of the enzymes and proteins involved in the production and accumulation of the lipids in biodiesel resources[J]. 2017.
  8. Gholampour-Faroji N, Haddad-Mashadrizeh A, Mirahmadi M, et al. In-silico Evidences of Regulatory Roles of WT1 Transcription Factor Binding Sites on the Intervening Sequences of the Human Bcl-2 Gene[J]. Current Bioinformatics, 2017, 22.
  9. Sechler A J, Tancos M A, Schneider D J, et al. Whole genome sequence of two Rathayibacter toxicus strains reveals a tunicamycin biosynthetic cluster similar to Streptomyces chartreusis[J]. Plos One, 2017, 12(8):e0183005.
  10. Hamid M H, Rozano L, Yeong W C. Analysis of MAP kinase MPK4/MEKK1/MKK genes of Carica papaya L. comparative to other plant homologues:[J]. Bioinformation, 2017, 13(2):31-41.
  11. Vu S K, Bitzer D L. Modeling ribosome dynamics to optimize heterologous protein production: U.S. Patent Application 15/541,941[P]. 2017-12-28.
  12. Mura M, Combredet C, Najburg V, et al. Nonencapsidated 5′ Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5[J]. Journal of Virology, 2017, 91(20): e00643-17.
  13. Maksum I P, Riswanto N, Rostinawati T, et al. Extracellular secretion recombinant of human epidermal growth factor (hEGF) using pectate lyase B (PelB) signal peptide in escherichia coli BL21 (DE3)[J]. International Journal of Research in Pharmaceutical Sciences, 2017, 8(1): 33-40.
  14. Sivasankaran K, Mathew P, Anand S, et al. Complete mitochondrial genome sequence of fruit-piercing moth Eudocima phalonia, (Linnaeus, 1763) (Lepidoptera: Noctuoidea)[J]. Genomics Data, 2017, 14:66–81.
  15. Gultyaev A P, Spronken M I, Richard M, et al. Subtype-specific structural constraints in the evolution of influenza A virus hemagglutinin genes[J]. Scientific Reports, 2016, 6:38892.
  16. Saadat S, Sajadi M M, Alikhani M Y, et al. Production of a chimeric protein and its potential application in sero-diagnosis of Mycoplasma hominis infection[J]. Journal of microbiological methods, 2018, 144: 186-191.
  17. Milholland B, Dong X, Zhang L, et al. Differences between germline and somatic mutation rates in humans and mice[J]. Nature communications, 2017, 8: 15183.
  18. Comtois F. Optimisation du promoteur CR5 inductible au cumate[J]. 2016.
  19. Karyal C. Investigation of hidden lipoproteins in Neisseria meningitidis[D]. Kingston University, 2016.
  20. Agarwal S, Agarwal S, Biancucci M, et al. Induced autoprocessing of the cytopathic Makes Caterpillars Floppy-like effector domain of the Vibrio vulnificus MARTX toxin.[J]. Cellular Microbiology, 2015, 17(10):1494.
  21. Mcclellan S A, Ekanayaka S A, Li C, et al. Thrombomodulin Protects Against Bacterial Keratitis, Is Anti-Inflammatory, but Not Angiogenic[J]. Invest Ophthalmol Vis Sci, 2015, 56(13):8091-8100.
  22. Guerra ÁP et al (2016). Production of recombianant proteins from Plasmodium falciparum in Escherichia coli. Biomedica : revista del Instituto Nacional de Salud, 36(0):97-108.
  23. Romanello M et al (2016). Histone H3.3 promotes lgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. The EMBO journal, 35(13):1452-1464.