Recombinant Proteins

BiologicsCorp(BIC) mainly manufactures such recombinant proteins: cytokines(Interleukin, Interferon), chemokines(Eoxtain, MIP, GRO), growth factors(EGF, GMCSF, MIP), viral antigens(preS1, PreS2), enzymes(PP, UC), hormones(PTH, exedin), neurotrophins(NGF, BDNF, NT-4) and CD antigens. The genes of these products come from different species: mouse, rat, human, rhesus macaque and canine. In order to make the gene express efficiently, we have launched different expression systems: E.coli system, mammalian system, yeast system and insect system. Also, we developed some technical platforms, like codon optimization and supernateINTM protein expression to ensure our guaranteed services.

Recombinant Protein Customization Services


Introduction of Recombinant Proteins

Protein is a large biological molecule or macromolecule, which is composed of one or more chains of amino acid residues. Amino acids are made up of carbon, hydrogen, oxygen, nitrogen and sulfur.

Protein synthesis is the process where proteins are produced or synthesized. Proteins are assembled from amino acids which are encoded using the information in genes. The genetic code is a set of three-nucleotide sets called codons and each three-nucleotide combination designates an amino acid. Proteins play an important role in our cells, which are involved in virtually all cell functions. Some are involved in structural support(keratin, collagen, and elastin), while others are involved in bodily movement(actin and myosin), or in defense against germs(antibody).

Recombinant proteins are novel proteins, which are often used to study functions and structure of nature proteins. There are basically two methods for producing recombinant proteins. One is molecular cloning, a laboratory method used to make recombinant DNA. The other method is the polymerase chain reaction which is used for the replication of the specific DNA sequence. Between the two methods, PCR is mainly used in the test tube, without living cells. The recombinant DNA is need to integrated to a cloning vector for expression. Generally, plasmids or viruses can be used as cloning vector. The option of vector for molecular cloning relies on the option of host organism, the size of the DNA to be cloned, and the way in which the foreign DNA is to be expressed.

Recombinant proteins have been widely used for therapeutic purposes, such as for hemophilia, diabetes, cancers, dwarfism etc. In a long term, clinical application of recombinant proteins might be replaced by stem cell therapy or genetic treatment, but currently they are still the main trend. We are very pleasure to introduce some of our products to you. Interleukin is a kind of cytokine, whose major use is to stimulate the growth and development of a variety of immune cells and stimulate the production of chemokines. The major use of EGF is associated with cellular proliferation, differentiation and survival. GM-CSF is a cytokine that functions as a white blood cell growth factor, which stimulates stem cells to produce granulocytes and monocytes. They belong to growth factor.