Phosphorylation is the addition of a phosphate (PO43−) group to a protein or other organic molecule.
Protein phosphorylation is a post-translational modification of proteins in which a serine, a threonine or a tyrosine residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group.
Protein phosphorylation plays a significant role in a wide range of cellular processes, because it alters the function and activity of many protein enzymes. Protein phosphorylation is essential for pathway activation in cellular regulation, cell signaling and growth. Especially, the regulation of proteins by phosphorylation is one of the most common modes of regulation of protein function and is often termed "phosphoregulation".
Polyclonal antibodies can recognize and bind with high affinity and specificity to unique epitopes across a broad spectrum of biomolecules. Phospho-specific antibodies are used not only to detect phosphorylated proteins or peptides, but also to measure changes in their level and specificity of modification by processes of phosphorylation.
BiologicsCorp can provide a wide variety of phospho-specific antibodies with our professional techniques. Our phospho-specific antibodies can be applied to western blotting, immunohitochemistry, immunofluorescence, etc.