BMP-2(Bone Morphogenetic Protein 2), Human Recombinant, E.coli
BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. BMP-2, one of the main growth factors implicated in growth and regeneration of bone and cartilage, exhibits pronounced osteoinduction properties. Under normal growth conditions, BMP-2 is localized in bone tissue as a complex with high molecular glycosaminoglycans, and is released in response to bone damage, resulting in the stimulation of differentiation of mesenchymal cells into osteoblasts and induction of cell proliferation.
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QA data of rhBMP-2
|Full Name||Bone Morphogenetic Protein-2 Human Recombinant|
|Synonyms||BMP-2; BMP2; Bone Morphogenetic Protein 2; BMP2A|
|Amino Acid Sequence||The sequence of the N-terminal amino acids was determined as Met-Gln-Ala-Lys-His.|
|Molecular Weight||Bone Morphogenetic Protein-2 Human Recombinant was expressed in E. coli as a homodimeric, non-glycosylated polypeptide chain containing 115 amino acids. BMP2 exhibits a Molecular Weight of approximately 26 kDa as revealed by SDS-PAGE (under non-reducing conditions).|
|Purity||>98% as determined by SDS-PAGE and HPLC|
|Endotoxin||Endotoxin level was found to be <0.1 ng/µg(1EU/µg) by a LAL gel clot method.|
|Formulation||Lyophilized from a 50mM acetic acid solution, filtered by 0.2 µm membrane.|
|Reconstitution||To reconstitute the protein, add sterile 100mM AcOH (acetic Acid) to the lyophilized protein and make a preparation with a concentration ≥0.1mg/ml. The preparation can be diluted into other appropriate buffers if necessary. Cautions should be taken to avoid bacterial growth, resulting in potential contamination with endotoxin.|
|Stability||The lyophilized protein is stable at room temperature (≈3 weeks) and at -20°C (≥ 2 years from the date of receipt).Upon reconstitution, it can be stored at 4°C (≤ 7 days) or at -20°C (≤ 6 months). For long term storage, please store at -80°C and the addition of a carrier protein (0.1% HSA or BSA) is recommended.Avoid frequent freeze-thaw cycles.|
|Biological Activity||Determined by its ability to induce alkaline phosphatase production in ATDC-5 cells. The ED50 is <50ng/ml.|
|Usage||FOR LABORATORY RESEARCH USE ONLY. Not intended for diagnostic or therapeutic purposes.|
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