BMP-2(Bone Morphogenetic Protein 2), Human Recombinant, E.coli

BMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. BMP-2, one of the main growth factors implicated in growth and regeneration of bone and cartilage, exhibits pronounced osteoinduction properties. Under normal growth conditions, BMP-2 is localized in bone tissue as a complex with high molecular glycosaminoglycans, and is released in response to bone damage, resulting in the stimulation of differentiation of mesenchymal cells into osteoblasts and induction of cell proliferation.

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QA data of rhBMP-2

rhbmp-2 activity, mass specification and sds-page

Full Name Bone Morphogenetic Protein-2 Human Recombinant
Synonyms BMP-2; BMP2; Bone Morphogenetic Protein 2; BMP2A
Source E. coli
Amino Acid Sequence The sequence of the N-terminal amino acids was determined as Met-Gln-Ala-Lys-His.
Molecular Weight Bone Morphogenetic Protein-2 Human Recombinant was expressed in E. coli as a homodimeric, non-glycosylated polypeptide chain containing 115 amino acids.  BMP2 exhibits a Molecular Weight of approximately 26 kDa  as revealed by SDS-PAGE (under non-reducing conditions).
Purity >98% as determined by SDS-PAGE and HPLC
Endotoxin Endotoxin level was found to be <0.1 ng/µg(1EU/µg) by a LAL gel clot method.
Formulation Lyophilized from a 50mM acetic acid solution, filtered by 0.2 µm membrane.
Reconstitution To reconstitute the protein, add sterile 100mM AcOH (acetic Acid) to the lyophilized protein and make a preparation with a concentration ≥0.1mg/ml.  The preparation can be diluted into other appropriate buffers if necessary. Cautions should be taken to avoid bacterial growth, resulting in potential contamination with endotoxin.
Stability The lyophilized protein is stable at room temperature (≈3 weeks) and at -20°C (≥ 2 years from the date of receipt).Upon reconstitution, it can be stored at 4°C (≤ 7 days) or at -20°C (≤ 6 months). For long term storage, please store at -80°C and the addition of a carrier protein (0.1% HSA or BSA) is recommended.Avoid frequent freeze-thaw cycles.
Biological Activity Determined by its ability to induce alkaline phosphatase production in ATDC-5 cells. The ED50 is <50ng/ml.
Usage FOR LABORATORY RESEARCH USE ONLY.  Not intended for diagnostic or therapeutic purposes.

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Product Code: CY115
Availability: In Stock
Price: $0.00
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