Exendin-4 Recombinant, E.coli
Exenatide is an incretin mimetic, a synthetic form of the naturally occurring exendin-4 isolated from the saliva of the Gila monster (Heloderma suspectum). Exenatide has 53% amino acid sequence identity with human glucagon-like peptide-1 (GLP-1), and has been widely used as an adjunctive therapy. Exendin-4 is a molecule currently used, is a glucagon like peptide-1 receptor agonist. Exendin-4 exerts insulinotropic effects and has multiple glucose regulatory functions through activation of GLP-1 receptor in the mammalian cells. It binds and activates the Glucagon-Like Peptide-1 Receptor (GLP-1R), thus stimulation of insulin secretion, suppression of glucagon secretion, enhancement of beta-cell mass, slowing of gastric emptying, and inhibition of food intake.
| Description | Exendin-4 Recombinant is a novel 39-amino acids peptide having a molecular mass of 4186.7 Dalton, which shares 53%, sequence homology with GLP-17-36 amide and interacts with the same membrane receptor. The Exendin-4 is purified by proprietary chromatographic techniques. |
| Synonyms | Exenatide. |
| Source | Escherichia Coli. |
| Amino Acid Sequence | The sequence determined and was found to be His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser. |
| Purity | >96% as determined by SDS-PAGE and HPLC |
| Formulation | Sterile Filtered White lyophilized (freeze-dried) powder. The Exendin-4 peptide was lyophilized after extensive dialyses against 20mM PBS and contains 4% mannitol. |
| Stability | The lyophilized form of the protein is stable at room temperature for 3 weeks and at -20°C for at least 2 years from the date of receipt. Upon reconstitution, the protein should be stored at 4°C for no more than 7 days. The protein is stable at -20°C for six months. For long term storage, please store at -80°C and the addition of a carrier protein (0.1% HSA or BSA) is recommended. Please prevent freeze-thaw cycles. |
| Biological Activity | 1. Regulates Glucose levels rapidly 2. Reduces Insulin resistence 3. Reduces Glucagon 4. Reduces HbA1c 5. Stimulates beta cell growth which stimulates insulin production. |
| Solubility | It is recommended to reconstitute the lyophilized Exendin Recombinant in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Usage | LABORATORY RESEARCH USE ONLY. Not intended for diagnostic or therapeutic purposes. |
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