Interleukin-17 (IL-17) family

The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses.

Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many

unique structural and functional features. Members of this family have a highly conserved C-terminus containing a cysteine-knot fold structure. Most IL-17 proteins are secreted as disulfide-linked dimers, with the exception of IL-17B, which is secreted as a non-covalent homodimer.