Protein Phosphatase Inhibitor-1 Human Recombinant
PPP1R1A is an inhibitor of protein-phosphatase 1. IPP-1 protein plays important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP elevate IPP-1 activity. PPP1R1A activation caused cAMP to control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium, IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation.
| Description | PPP1R1A Human Recombinant fused with His tag at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 179 amino acids and having a molecular mass of 20 kDa. The PPP1R1A is purified by proprietary chromatographic techniques. |
| Synonyms | IPP1, IPP-1, I-1, PPP1R1A, PPI-1, Protein Phosphatase Inhibitor-1, Protein phosphatase 1 regulatory subunit 1A. |
| Source | Escherichia Coli. |
| Amino Acid Sequence | MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH. |
| Purity | >96% as determined by SDS-PAGE and HPLC |
| Formulation | Sterile Filtered colorless solution. The PPP1R1A solution contains 50mM Tris pH-8, 0.1mM PMSF, 1mM EDTA, 1mM DTT & 10% glycerol. |
| Stability | The lyophilized form of the protein is stable at room temperature for 3 weeks and at -20°C for at least 2 years from the date of receipt. Upon reconstitution, the protein should be stored at 4°C for no more than 7 days. The protein is stable at -20°C for six months. For long term storage, please store at -80°C and the addition of a carrier protein (0.1% HSA or BSA) is recommended. Please prevent freeze-thaw cycles. |
| Usage | LABORATORY RESEARCH USE ONLY. Not intended for diagnostic or therapeutic purposes. |
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Product Code: EN767
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