PPP1CC (Protein Phosphatase 1, Catalytic Subunit Gamma), Human Recombinant, E.coli
Phosphatases (PSPs) have multiple sub-families, with the largest family being the PhosphoProtein Phosphatases (PPP). The PPP family consists of PP1, PP2A, PP3 (PP2B/Calcineurin), PP4, PP5, PP6 and PP7. Among the PPP family, Protein Phosphatase 1 (PP1, ~38.5 kDa) is the a highly characterized serine/threonine phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting proteins (PIPs). PP1 regulates diverse, essential cellular processes such as cell cycle progression, protein synthesis, carbohydrate metabolism, transcription and neuronal signaling. Two isoforms of phosphoprotein phosphatase 1, PPP1CC1 and PPP1CC2, are translated from alternatively spliced transcripts of a single gene, PPP1CC, and differ only at their extreme C-termini. PPP1CC is vital for cell division and takes part in the regulation of protein synthesis, muscle contractility and glycogen metabolism.
| Description | PPP1CC Human Recombinant produced in E. coli is a single polypeptide chain containing 343 amino acids (1-323) and having a molecular mass of 39.1kDa. PPP1CC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
| Synonyms | Protein phosphatase 1 catalytic subunit gamma isozyme/isoform, Protein phosphatase 1C catalytic subunit, serine/threonine phosphatase 1 gamma, serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP1gamma, PPP1G, EC 3.1.3.16. |
| Source | E.coli. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE KKKPNATRPV TPPRGMITKQ AKK. |
| Purity | >96% as determined by SDS-PAGE and HPLC |
| Formulation | Sterile Filtered colorless solution. The PPP1CC solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol. |
| Stability | The lyophilized form of the protein is stable at room temperature for 3 weeks and at -20°C for at least 2 years from the date of receipt. Upon reconstitution, the protein should be stored at 4°C for no more than 7 days. The protein is stable at -20°C for six months. For long term storage, please store at -80°C and the addition of a carrier protein (0.1% HSA or BSA) is recommended. Please prevent freeze-thaw cycles. |
| Usage | LABORATORY RESEARCH USE ONLY. Not intended for diagnostic or therapeutic purposes. |
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Product Code: EN765
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