A breakthrough in cancer treatment: GLUT1 crystal structure

GLUT1 Structure
Overall structure of the human glucose transporter GLUT1

GLUT1 crystal structure
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Introduction of GLUT1 transporter
Glucose transporter 1 (or GLUT1) with highly conservatism, facilitates the transport of glucose across the plasma membranes of mammalian cells. read more in wikipedia

GLUT1 Inhibitor
WZB117 - A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
Fasentin - a small molecule inhibitor of the intracellular domain of GLUT1 preventing glucose uptake.

GLUT1 Deficiency syndrome
GLUT1 deficiency syndrome is a disorder affecting the nervous system that can have a variety of neurological signs and symptoms. GLUT1 deficiency syndrome is a rare disorder. Approximately 500 cases have been reported worldwide since the disorder was first identified in 1991. read more